Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain.
نویسندگان
چکیده
Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues(~4mm) deep below the cortex.
منابع مشابه
Dedication This work is dedicated to
In-vivo Optical Imaging and Spectroscopy of Cerebral Hemodynamics Chao Zhou Arjun G. Yodh Functional optical imaging techniques, such as diffuse optical imaging and spectroscopy and laser speckle imaging (LSI), were used in research and clinical settings to measure cerebral hemodynamics. In this thesis, theoretical and experimental developments of the techniques and their in-vivo applications r...
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عنوان ژورنال:
- Optics express
دوره 14 3 شماره
صفحات -
تاریخ انتشار 2006